Endocrine Abstracts

Bronchopulmonary neuroendocrine tumors (BP-NETs) comprise 20% of all lung cancers. Typical low grade carcinoid tumors (TC) represent the majority of BP-carcinoids. Intermediate grade atypical carcinoid tumors (AC) are less often encountered but more aggressive. Although metastatic dissemination to mediastinal lymph nodes as well as liver, skeleton, central nervous system, skin and mammary glands is well known, the involvement of endocrine glands is really rare.<p class="ab...

Introduction: Individuals with glycogen storage disease type 1b (GSD1b) usually have low blood glucose and are at constant risk of hypoglycemia. We recently hospitalized a pregnant woman with GSD1b, where despite nutritional management, her glycemia values were almost unwaveringly towards the lower physiological limits. In a recent study (Rossi et al. Orphanet Journal of Rare Diseases 2020; 15: 99, https://doi.org/1...

Introduction: This study aims to assess the performance of ultrasound using Kwak-TIRADS as the primary diagnostic tool for estimating papillary thyroid carcinoma (PTC) risk in thyroid nodules within the high-prevalence region of Crete, Greece.Methods: A retrospective analysis was conducted on 802 thyroid nodules collected between 2018 and 2021. Nodules were categorized based on Kwak-TIRADS and compared against the Bethesda System for Reporting Thyroid Cy...

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. Genomic studies have shown the presence of inactivating mutations of the NCoR gene in human tumours and we have found that NCoR depletion with siRNA in hepatocarcinoma SK-hep1 cells enhances invasion, tumour growth and metastasis in nude mice, while expression of the thyroid hormone receptor β (TRβ) increases NCoR levels, repr...

Introduction: Tertiary hyperparathyroidism can be developed in cases of persistent or non-curable secondary hyperparathyroidism or in any other case of long-standing hypocalcemia that leads to the autonomous function of at least one parathyroid gland. We present a case of a man with tertiary hyperparathyroidism and excessive maxilla swelling and extensive bone lesions.Presentation: A 32 years old man, with chronic renal failure on dialysis for twelve yea...

Introduction: Adrenal cystic lesions are rare. Differential diagnoses include pseudocysts, echinococcal cysts, hemangiomas, cystic pheochromocytomas, adrenal hematomas and lymphangiomas. We present here a rare case of an adrenal lymphangioma.Case report: A 35-year old man was referred to our department for investigation of a right adrenal cystic mass, incidentally found during an abdominal ultrasound. The patient was completely asymptomatic and had a med...

Introduction: IgG4 Related Hypophysitis (IgG4-RH) is a newly recognized form of hypophysitis. It usually appears as part of IgG4-Related Disease (IgG4-RD), an immune mediated disease, with manifestations in many organs. Isolated hypophysitis without other IgG4-RD manifestations is rare.Presentation: A 64 years old female referred to our department for further investigation of a 9 month history of fatigue, muscle weakness, recurrent episodes of right temp...

Objective: Whereas parathyroidectomy (PTx) has an established benefit in patients with symptomatic primary hyperparathyroidism (PHPT), its efficacy in patients with mild (asymptomatic) PHPT has not been proven. The aim of this study was to systematically investigate and meta-analyze the best available evidence from randomized-controlled trials regarding the efficacy of PTx on fracture risk (primary endpoint), as well as bone mineral density (BMD), serum calcium concentrations,...

Background: Carpal tunnel syndrome (CTS) is common in patients with acromegaly, with a reported prevalence of 19–64%. We have studied CTS in a large national cohort of patients with acromegaly, and the temporal relationship between the diagnosis of the two diseases.Methods: Retrospective nationwide cohort study including patients diagnosed with acromegaly in Sweden between 2005 and 2017. Patients with acromegaly were identified in the Swedish Natio...

Introduction: Postmenopausal virilization with acute onset and rapid progression requires a thorough investigation for the presence of adrenal or ovarian tumor. We present here a challenging case of a radiologically not visible and rare androgen-hypersecreting ovarian tumor.Case report: A 71-year old postmenopausal woman presented to our department for the investigation of terminal hair growth, of recent onset and rapid progression, on the upper lip, chi...